Sperm appears to be unfazed by long stints in outer space.
In the longest biological experiment on the International Space Station yet, freeze-dried mouse sperm remained viable after nearly six years in space.
Studying how space radiation affects reproduction is tricky. Instruments on Earth can’t perfectly mimic space radiation, and the ISS lacks freezers for long-term cell storage. So biologist Teruhiko Wakayama of the University of Yamanashi in Kōfu, Japan and colleagues freeze-dried sperm, allowing it to be stored at room temperature. The team then sent sperm from 12 mice to the space station, while keeping other sperm from the same mice on the ground.
After returning the sperm cells to Earth, rehydrating them and injecting them into fresh mouse eggs, the team transferred those embryos to female mice. About 240 healthy space pups were born from sperm kept on the ISS for nearly three years; about 170 others were born from sperm kept on the space station for nearly six years. Genetic analyses revealed no differences between these space pups and mice born from sperm stored on the ground. Space pups that mated as adults had healthy children and grandchildren.
Though these results are promising, they may not capture the full the effects of space radiation, since the ISS is partially shielded from radiation by Earth’s magnetic field.
In the longest biological experiment on the International Space Station yet, freeze-dried mouse sperm remained viable after nearly six years in space.
Studying how space radiation affects reproduction is tricky. Instruments on Earth can’t perfectly mimic space radiation, and the ISS lacks freezers for long-term cell storage. So biologist Teruhiko Wakayama of the University of Yamanashi in Kōfu, Japan and colleagues freeze-dried sperm, allowing it to be stored at room temperature. The team then sent sperm from 12 mice to the space station, while keeping other sperm from the same mice on the ground.
After returning the sperm cells to Earth, rehydrating them and injecting them into fresh mouse eggs, the team transferred those embryos to female mice. About 240 healthy space pups were born from sperm kept on the ISS for nearly three years; about 170 others were born from sperm kept on the space station for nearly six years. Genetic analyses revealed no differences between these space pups and mice born from sperm stored on the ground. Space pups that mated as adults had healthy children and grandchildren.
Though these results are promising, they may not capture the full the effects of space radiation, since the ISS is partially shielded from radiation by Earth’s magnetic field.
